All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional.
The Lupus Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lupus Hub cannot guarantee the accuracy of translated content. The Lupus Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which the pathophysiology includes immune dissonance, genetic predisposition, epigenetic dysregulation, and dysbiosis of microbiota. SLE is life-threatening, more prevalent in women, and characterized by organ damage and a relapsing remitting course. SLE has highly heterogeneous clinical manifestations, which overlap with many other rheumatoid diseases, hematopoietic malignancies, and infections, which can hamper diagnosis. SLE is most likely to affect the skin, joints/muscles, kidneys, and blood vessels.