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Lupus nephritis (LN) is the most prevalent serious complication of systemic lupus erythematosus (SLE). Given the limitations with existing diagnostic procedures, there’s an urgent need for a reliable biomarker with high predictive value for LN. Li et al.1 recently published an article in Journal of Autoimmunity, identifying and validating novel urinary biomarkers capable of distinguishing active renal involvement in SLE. Below, we summarize their key findings.
Figure 1. Validation of novel urine biomarkers by ELISA*
AR, active renal; AUC, area under the curve; iSLE, inactive systemic lupus erythematosus; ROC, receiver operating characteristic.
*Adapted from Li, et al.1
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