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CAR therapy
Chimeric antigen receptor (CAR) therapy involves treatment of patients with their own immune cells, which are taken, genetically modified to express the CAR construct, and then infused back into the patient. In SLE, this mainly involves the use of engineered T cells, which express a targeted B-cell antigen, such as anti-CD19 or B-cell maturation antigen (BCMA), to deplete B cells or limit B-cell function.
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